GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs7611238 | 1 | rs13324903 | chr3:195086647 | C3orf21 | chr3:194789015-194991895:- | -0.27 | -5.27 | 2.29E-7 | Body mass index |
| BLCA | cis | rs9815354 | 1 | rs13325965 | chr3:41914942 | ULK4 | chr3:41288091-42003660:- | 0.62 | 9.23 | 1.83E-18 | Diastolic blood pressure |
| BLCA | cis | rs7714584 | 1 | rs13361189 | chr5:150223387 | LOC134466 | chr5:150310000-150326146:- | 0.48 | 5.93 | 6.69E-9 | Crohn's disease |
| BLCA | cis | rs1577917 | 1 | rs1337844 | chr6:86677273 | SNHG5 | chr6:86386726-86388451:- | -0.5 | -8.81 | 4.42E-17 | Response to antipsychotic treatment |
| BLCA | cis | rs1577917 | 1 | rs1337850 | chr6:86729103 | SNHG5 | chr6:86386726-86388451:- | -0.53 | -9.35 | 7.51E-19 | Response to antipsychotic treatment |
| BLCA | cis | rs9309473 | 1 | rs13383871 | chr2:73631779 | ALMS1P | chr2:73872046-73912692:+ | 0.32 | 4.65 | 4.51E-6 | Metabolite levels |
| BLCA | cis | rs13385191 | 1 | rs13385191 | chr2:20888265 | C2orf43 | chr2:20883803-21022827:- | -0.4 | -5.92 | 7.11E-9 | Prostate cancer |
| BLCA | cis | rs6715284 | 1 | rs13398075 | chr2:202376269 | PPIL3 | chr2:201735680-201753999:- | 0.44 | 4.1 | 5.14E-5 | Rheumatoid arthritis |
| BLCA | cis | rs9309473 | 1 | rs13398956 | chr2:73720258 | ALMS1P | chr2:73872046-73912692:+ | 0.34 | 5.03 | 7.46E-7 | Metabolite levels |
| BLCA | cis | rs6715284 | 1 | rs13408294 | chr2:202171573 | PPIL3 | chr2:201735680-201753999:- | -0.44 | -4.92 | 1.3E-6 | Rheumatoid arthritis |
| BLCA | cis | rs9309473 | 1 | rs13421462 | chr2:73719875 | ALMS1P | chr2:73872046-73912692:+ | 0.33 | 4.77 | 2.63E-6 | Metabolite levels |
| BLCA | cis | rs9309473 | 1 | rs13428235 | chr2:73633430 | ALMS1P | chr2:73872046-73912692:+ | 0.33 | 4.87 | 1.65E-6 | Metabolite levels |
| BLCA | cis | rs9309473 | 1 | rs13431267 | chr2:73782200 | ALMS1P | chr2:73872046-73912692:+ | 0.35 | 5.1 | 5.44E-7 | Metabolite levels |
| BLCA | cis | rs9309473 | 1 | rs13432605 | chr2:73810981 | ALMS1P | chr2:73872046-73912692:+ | 0.36 | 5.2 | 3.22E-7 | Metabolite levels |
| BLCA | cis | rs5758659 | 1 | rs134869 | chr22:42652074 | C22orf32 | chr22:42475699-42480287:+ | 0.2 | 5.34 | 1.63E-7 | Cognitive function |